Colistin monotherapie
WebDec 23, 2024 · The patients were divided into colistin plus carbapenem therapy and colistin monotherapy groups. The primary outcome was 14-day mortality. The secondary outcomes were in-hospital mortality, clinical improvement at days 2 and 14, and microbiological improvement at day 14.Results: Of 160 cases meeting criteria for CRAB … WebNational Center for Biotechnology Information
Colistin monotherapie
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WebOct 19, 2024 · In total, 26 patients in the colistin sulfate monotherapy group and 54 patients in the combined therapy group were recruited. The clinical efficacy in the combined therapy group (94.4%) was significantly higher than that in the colistin monotherapy group (73.1%) ( p = 0.007); however, the 28-day mortality and length of hospital stay were not ... WebSep 1, 2008 · Moreover, a major concern regarding colistin monotherapy is the potential problem of heteroresistance among Gram-negative bacterial populations exposed to colistin alone [8, 14]. Currently, there is a dearth of data regarding the clinical value of combination therapy and the clinical impact of heteroresistance.
WebNov 13, 2024 · Polymyxins (Colistin and Polymyxin B) Colistin (or polymyxin E) is a mixture of cyclic polypeptide antibiotics with activity against most species in the order Enterobacteriales (except for Serratia marcescens and Proteus, Providencia, Morganella, and Hafnia species), P. aeruginosa, A. baumannii, and some S. maltophilia strains … WebFeb 15, 2024 · This trial was designed to compare the effectiveness of colistin monotherapy versus colistin–meropenem combination therapy among patients with severe infections caused by carbapenem-resistant …
WebAlthough synergistic antibiotic activity with colistin combined to rifampicin or carbapenems has been shown in vitro ,2,3the superiority of such combination therapy has never been demonstrated in patients.4–6Intravenous colistin monotherapy is therefore often used as salvage therapy in the treatment of patients with VAP caused by multidrug-resistant … WebNov 24, 2015 · Meta-analysis of colistin monotherapy Clinical outcome. Four studies reported the clinical response, including 133 patients (83 with colistin treatment and 50 with other antibiotics).
WebNov 28, 2024 · (1) Introduction: Colistin combination therapy with other antibiotics is a way to enhance colistin activity. The purpose of this meta-analysis was to compare the …
WebDec 1, 2024 · In Cheng’s analysis [27] including five RCTs, there was no significant difference between colistin monotherapy and colistin-based combination therapy in all-cause mortality (RR 1.03; 95% CI 0.89–1.20), infection-related mortality (RR 1.23, 95% CI 0.91–1.67) and microbiologic response (RR 0.86, 95% CI 0.72–1.04). But in that meta ... thakur complexWebApr 10, 2024 · Notably, 53 (47.7%) patients had bloodstream infections, while 58 (52.3%) had pneumonia. Colistin was combined in 96.1%, 80.4%, and 5.8% of cases with … synonyms for towards the endWebFeb 22, 2024 · 2.1. Colistin Chemical Profile, Mechanism of Action. Colistin is an amphiphilic lipopeptide molecule consisting of several parts—a cyclic heptapeptide, forming the hydrophilic part, linked by a tripeptide bridge with a fatty acid, representing the hydrophobic part (see Figure 1) [].Five diaminobutyric acid residues are attached to this … thakur constructionWebApr 12, 2024 · Clinical and Laboratory Standards Institute (CLSIs’) endorsement on use of colistin in conjunction with one or more antibiotics rather than monotherapy (Dhandapani et al. 2024), recommendation of glycopeptides for intrinsically resistant Gram-negative bacteria in combination with colistin (Armengol et al. 2024) and the synergism exhibited … synonyms for track recordWebJan 1, 2024 · Inhaled colistin monotherapy also showed fair effectiveness, both microbiological and clinical. These were in accordance with the outcomes of studies … synonyms for to whom it may concernsynonyms for toxic peopleWebA systematic review including patients affected by HAP or VAP due to MDR Pseudomonas aeruginosa reported respectively a clinical success and microbiological eradication in 70.4% and 71.3% of cases with inhaled colistin monotherapy . No evidence for inhaled colistin in association with cefiderocol or meropenem/fosfomycin combination therapy ... thakur complex kandivali